Gut restricted-7

Research use only, not for human use.

Gut restricted-7 (GR-7) is a covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. It decreases gut bacterial BSHs and decreases deconjugated bile acid levels in the feces of mice.

Gut restricted-7 (GR-7) is a covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. It decreases gut bacterial BSHs and decreases deconjugated bile acid levels in the feces of mice.(In Vitro):Gut restricted-7 (60 μM) does not affect the epithelial barrier integrity of Caco-2 cells, suggesting that this compound is relatively nontoxic.?Gut restricted-7 also does not affect microbial biomass.(In Vivo):The C57BL/6 mice fed with either powdered chow containing 0.09% Gut restricted-7 (w/w) for 1 d day or powdered chow alone.?Gut restricted-7 significant inhibits the BSH activity in the feces of inhibitor-treated mice 8 h post-diet change.?20picomol/mg wet mass (~20 μM) of Gut restricted-7 in cecal contents is detected.

GR-7

Cell Cycle/DNA Damage

Potassium Channel

CDK1; CDK2; CDK3; CDK5

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2553218-46-3

510.6

C25H40FNaO6S

>98% (HPLC)

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O=C(CF)CC[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](OS(=O)(O[Na])=O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C

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(-20℃)

With Ice Pack

≥ 2 years